THE EFFECTS OF hyCURE® GEL ON THE RATE OF WOUND HEALING IN NORMAL MICE.

Impaired wound healing often results in prolonged hospitalization with an increased chance of infection. A commercially available Type I collagen hydrolysate, hyCURE® GEL, proposes to enhance the rate of healing in chronic and acute wounds and dermal ulcers. This study evaluated the effect of topical application of hyCURE® GEL on wound healing in normal mice. Two full-thickness surgical wounds (one experimental the other control) were made on the dorsum of twenty mice ages 8-12 weeks and weighing 35-45 g. The experimental wound received topical application of hyCURE® GEL for 12 consecutive days starting at wounding. The rate of wound healing was measured by tracing the perimeter of the wound of transparency film for twelve consecutive days. The percent wound closure was then determined using computerized planimetry. Results demonstrated a faster rate of healing for the wound site that received the hyCURE® GEL. Statistically significant differences were observed on days 7,8 and 9 (ANOVA, p<.05). In conclusion, hyCURE® GEL accelerates wound closure. Its application to human wound healing is promising.